Sildenafil as its scientific name, sold under the brand name Viagra, Revatio and others, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PPH). It was originally developed by British scientists and then brought to market by the pharmaceutical company Pfizer.1 It acts by inhibiting cyclic GMP-specific phosphodiesterase type 5 (PDE5), an enzyme that promotes the degradation of cGMP, which regulates the flow of blood in the penis. Since its availability in 1998, sildenafil has been the main treatment for erectile dysfunction, its main competitors in the market are vardenafil (Levitra) and tadalafil (Cialis).
How this drug works or miraculous medicine: Part of the physiological process of erection includes the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. The NO binds to the receptors of the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to a relaxation of the smooth muscle of the corpus cavernosum, by vasodilation of the helicine arteries inside the penis. Vasodilatation increases the blood flow inside the penis, thus causing an erection.17 Robert F. Furchgott won the Nobel Prize in Physiology and Medicine in 1998 for the discovery and analysis of the endothelium-derived relaxation factor (EDRF in acronym in English: endothelium-derived relaxing factor), which was subsequently identified as nitric oxide or some other related compound very .
Sildenafil is a potent and selective specific inhibitor of phosphodiesterase type 5 (PDE5) that is responsible for the degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP competing for its binding to PDE5. The result is that cGMP stays longer inside the penis, producing more powerful and maintained erections. Active ingredients such as tadalafil (Cialis®) and vardenafil (Levitra®) act according to the same mechanism. Without sexual stimulation, and therefore, in the absence of activation of the NO / cGMP system, these drugs do not cause an erection.
This is a drug that you have to take with caution since it can cause very harmful effects for the health since they increase the cardiac activity in the body which can cause a heart attack.
Viagra in south africa is not so well seen by the men of that region since they consider it as something useless or without values according to their ethnic roots, although there are pharmacies where they sell them and there are varieties of brands and prices as we can see continuation on this website where these drugs are sold: https://www.viagrastoresa.com as you can see there are different brands and prices as to more famous: Cialis or other brands like, prozac, zenegra, ladygra enters other more. the effects of this drug cause an erection in the penis for an indefinite time depending on the amount of integrity in south africa this product is not well seen although many men use it to satisfy their sexual needs. Let’s learn about the Viagra.